Cervical Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Cervical Cancer, including details on symptoms, vaccine, screening, treatment, human papilloma virus (hpv), information.

The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target.

Kuroda M, Kiyono T, Oikawa K, Yoshida K, Mukai K

Department of Pathology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-8402, Japan. kuroda@tokyo-med.ac.jp

Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy.

Published 9 February 2005 in Br J Cancer, 92(2): 290-3.
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